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pentobarbital will reduce the extent or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Robust or average CYP3A inducers may possibly decrease cobimetinib systemic exposure by >80% and cut down its efficacy.In convulsive states, dosage of Nembutal Sodium Answer must be held

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